The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue of CDTR covers the period 1 – 7 March 2025 and includes updates on cholera associated with holy well water from Ethiopia, chikungunya, Avian flu detected in cats, SARS-CoV-2 variant classification, an overview of respiratory virus epidemiology in the EU/EEA, measles, Ebola, and MERS.