A prolonged genomic cluster of 20 human Listeria monocytogenes ST1607 infections has been reported to the European Centre for Disease Prevention and Control, with cases identified in Denmark (17), Germany (1), and Italy (2) since 2019. The number of cases has sharply increased after 2021. The most recent case was reported in March 2024 in Denmark, indicating an ongoing risk of further infections. Of 20 listeriosis cases, five have died (one due to another cause than L. monocytogenes infection), indicating high severity of infection particularly among elderly people with underlying chronic conditions.